A Biological Laboratory on Microelectronic Chip: Design, Fabrication, and Experimental Results
Subject Areas : electrical and computer engineeringE. Ghafar-Zadeh 1 * , Mohammad Sawan 2
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Abstract :
In this paper, a complementary metal–oxide semiconductor (CMOS) based Laboratory-on-Chip platform is presented for bacteria growth monitoring. This platform integrates a 0.18 µm CMOS chip with two microfluidic channels. The proposed CMOS chip manufactured by Taiwan Semiconductor Manufacturing Company (TSMC) features a differential capacitive sensor along with two reference and sensing interdigitized electrodes. Two microfluidic channels are thereafter implemented atop the electrodes through a direct-write assembly technique. These microchannels are filled with pure Luria-Bertani (LB) medium and Escherichia Coli (E. Coli) bacteria suspended in the LB medium, respectively. We demonstrate and discuss the experimental results by using two different bacteria concentrations in the order of 10^6 and 10^7 per 1 mL in the LB medium.
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